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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 101-111 doi: 10.1007/s11684-019-0698-4

Abstract: To isolate the potential somatic hypermutational tumor from microsatellite instability low/microsatellitestability (MSI-L/MSS) cases, we employed two commercial kits to determine MSI and forensic short tandemof the patients with GI exhibited STR alternation, including 100% (15/15) and 60% (141/235) of the microsatellitehigh instability and MSI-L/MSS cases, respectively. 30% (75/250) of the patients exhibited STR instabilityThe cutoff with 26.32% of the STR alternations covered all 15 MSI cases and suggested that it might be

Keywords： mismatch repair protein deficiency (MMR-D)     microsatellite instability (MSI)     short tandem repeats (STR    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: However, the combined expression of GATA3 and microsatellite instability (MSI) in upper tract urothelialMMR staining was in fact focally positive (<5%), we found that GATA3 was inversely associated with MSIMoreover, GATA3 /microsatellite stability (MS) tumors were correlated with advanced pT stage ( <0.001) and poor outcome ( =0.019 for CSS, =0.016 for DFS) compared with GATA3 /MSI ones.The GATA3 /MSI cases had unfavorable clinical outcomes compared with GATA3 /MSI cases ( =0.008 for CSS

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 60-65 doi: 10.15302/J-FASE-2015048

Abstract: Novel simple sequence repeat (SSR) markers were developed to evaluate their utility for genetic diversity and breeding studies of and related species. A total of 108 primer pairs were characterized by PCR amplification experiments. Among these, 61 were polymorphic and transferable to other citrus species. The number of alleles per locus ranged from 2 to 6, with an average of 2.37 alleles per locus. The expected heterozygosity and observed heterozygosity ranged from 0 to 0.83 and 0 to 1.00, respectively. These novel polymorphic SSR markers will be useful for citrus cultivar identification and evaluation as well as breeding studies.

Keywords： microsatellite     polymorphism     Poncirus trifoliata    

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Combustion instability detection using the wavelet detail of pressure fluctuations

JI Junjie, LUO Yonghao

Frontiers in Energy 2008, Volume 2, Issue 1,   Pages 116-120 doi: 10.1007/s11708-008-0019-0

Abstract: A combustion instability detection method that uses the wavelet detail of combustion pressure fluctuations

Keywords： comparison     wavelet approximation     pressure transducer     general pressure     consistent    

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Progress and Prospect of Seafloor Instability Research

Gao Weijian, Li Wei

Strategic Study of CAE 2023, Volume 25, Issue 3,   Pages 109-121 doi: 10.15302/J-SSCAE-2023.03.010

Abstract:

Seafloor instability and secondary submarine geohazards are widely presentHowever, formation mechanisms and controlling factors of seafloor instability are still poorly understoodTo improve the understanding, based on the history and development of seafloor instability, thisengineering geohazards risks, and summarizes popular quantitative analysis methods for seafloor instability, this study proposed the development direction and countermeasures of future seafloor instability

Keywords： seafloor instability     submarine geohazards     formation mechanisms     risk assessment     instability analysis    

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Size-dependent Elastic Instability of Gel CylinderWith Surface Stress

Huang Dianwu,Qiao Ling, Wang Shiji

Strategic Study of CAE 2007, Volume 9, Issue 4,   Pages 50-54

Abstract:

The elastic instability of a gel cylinder was researched with classicalThe non-classic boundary condition of the elastic instability has been educed by the energy functional So a criterion equation of the elastic instability can be got.Through the analysis of the equation, it is found that the elastic instability is relevant to the radius

Keywords： gel cylinder     elastic instability     intrinsic scale     surface effect    

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Modulational Instability of Optical Vortices in Engineered Saturable Media Review

D.G. Pires, N.M. Litchinitser

Engineering 2022, Volume 17, Issue 10,   Pages 31-43 doi: 10.1016/j.eng.2022.04.022

Abstract:

Propagation of light beams in turbid media such as underwater environments, fog, clouds, or biological tissues finds increasingly important applications in science and technology, including bio-imaging, underwater and free-space communication technologies. While many of these applications traditionally relied on conventional, linearly polarized Gaussian beams, light possesses many degrees of freedom that are still largely unexplored, such as spin angular momentum (SAM) and orbital angular momentum (OAM). Here, we present nonlinear light–matter interactions of such complex light beams with "rotational" degrees of freedom in engineered nonlinear colloidal media. By making use of both variational and perturbative approach, we consider non-cylindrical optical vortices, elliptical optical vortices, and higher-order Bessel beams integrated in time (HOBBIT) to predict the dynamics and stability of the evolution of these beams. These results may find applications in many scenarios involving light transmission in strongly scattering environments.

Keywords： Optical vortex     Orbital angular momentum     Modulation instability     Turbid media    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatelliteinstability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers.Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Underlying mechanism of the hydrothermal instability of Cu

Nadeen Al-Janabi,Abdullatif Alfutimie,Flor R. Siperstein,Xiaolei Fan

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 103-107 doi: 10.1007/s11705-015-1552-0

Abstract: Water induced decomposition of Cu (BTC) (BTC= benzene-1,3,5-tricarboxylate) metal-organic framework (MOF) was studied using dynamic water vapour adsorption. Small-angle X-ray scattering, Fourier transform infrared spectroscopy and differential scanning calorimetry analyses revealed that the underlying mechanism of Cu (BTC) MOF decomposition under humid streams is the interpenetration of water molecules into Cu-BTC coordination to displace organic linkers (BTC) from Cu centres.

Keywords： hydrothermal stability     metal-organic framework (MOF)     open metal sites (OMSs)     dynamic water vapour adsorption    

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MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 99-103 doi: 10.1007/s11684-007-0019-1

Abstract: We detected loss of heterozygosity (LOH) and microsatellite instabilities (MSI), as well as extron expressionLOH and MSI of the FHIT were detected by using PCR at 4 microsatellite loci: D3S 1300, D3S 4103, D3SResults show that the average frequencies of LOH and MSI of the FHIT gene in GC were 32.4% and 26.4%,There was no correlation between LOH and MSI of the FHIT gene in GC and the histological characteristicsThe frequency of MSI in GC without lymph node metastasis was significantly higher than that in GC with
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Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 263-274 doi: 10.1007/s11684-012-0215-5

Abstract:

Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia. In the past few decades, tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations. This review focuses on the basic mechanisms underlying the generation of chromosomal translocations. In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.

Keywords： DNA double strand breaks     chromosomal translocations     genomic instability     spatial proximity     carcinogenesis    

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p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by

Hui Han,Yanjia Chen,Zhengbin Zhu,Xiuxiu Su,Jingwei Ni,Run Du,Ruiyan Zhang,Wei Jin

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 320-329 doi: 10.1007/s11684-016-0463-x

Abstract:

Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.

Keywords： p-cresyl sulfate     atherosclerosis     plaque stability     vascular smooth muscle cell    

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Aerodynamic stability evolution tendency of suspension bridges with spans from 1000 to 5000 m

Frontiers of Structural and Civil Engineering doi: 10.1007/s11709-023-0980-z

Abstract: Aerodynamic instability owing to aerostatic and flutter-related failures is a significant concern inTo analyze the aerodynamic instability, streamlined single-box section (SBS), lattice truss section (We performed three-dimensional (3-D) full-mode flutter analysis and nonlinear aerostatic instabilityRegarding aerostatic instability, the instability wind speed decreases with span to approximately 3000gust wind speed, indicating the probability of aerostatic instability.

Keywords： suspension bridge     super long-span     finite element model     aerodynamic instability     aerodynamic configuration    

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Stability of an annular viscous liquid jet in compressible gases with different properties inside and outside of the jet

Chunji YAN, Maozhao XIE,

Frontiers in Energy 2010, Volume 4, Issue 2,   Pages 198-204 doi: 10.1007/s11708-009-0054-5

Abstract: A spatial linear instability analysis is conducted on an annular viscous liquid jet injected into compressibleTheoretical analysis reveals that there exist 9 dimensionless parameters controlling the instabilityThe Mach number plays a destabilizing role and the inner Mach number has a greater effect on the jet instability

Keywords： liquid jet     dominant wave number     compressibility     instability    

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Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training for anesthesiologists?

Yong G. Peng, Gregory M. Janelle

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 332-337 doi: 10.1007/s11684-012-0212-8

Abstract:

Bedside limited echocardiography, or focused cardiac ultrasound, continues to gain popularity in many emergency rooms, intensive care units, and operating rooms as a rapid method of assessing unstable patients. Effective monitoring of cardiovascular function in conditions like cardiac arrest or near-arrest is the crucial step to guide successful resuscitative efforts. Transesophageal echocardiography (TEE) has emerged as one of the preferred cardiac diagnostic and monitoring modalities in the intraoperative setting due to the fact that it is less invasive than many other monitors, is immediately accessible, and allows for continuous real-time monitoring of cardiac function. However, the minimum training requirements needed for the anesthesia provider to obtain the competency, knowledge, and skills for basic certification in perioperative TEE far exceed those developed for other medical specialties. We believe there is an urgent need to develop (1) practical guidelines for emergent perioperative TEE use for anesthesiologists and (2) a requisite educational curriculum to teach the basic skills necessary to aid in the diagnosis and treatment of cardiac arrest or near-arrest scenarios. The measures elucidated in this report summarize the efforts of the Department of Anesthesiology at the University of Florida in establishing the necessary steps to make this process not only practical, but accessible to all trainees. We hope that these collective efforts will provide more trainees the confidence in utilizing TEE to aid in establishing a diagnosis in critical situations.

Keywords： transesophageal echocardiography     curriculum     competency training     hemodynamic instability    

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Title Author Date Type Operation

Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

Journal Article

Combustion instability detection using the wavelet detail of pressure fluctuations

JI Junjie, LUO Yonghao

Journal Article

Progress and Prospect of Seafloor Instability Research

Gao Weijian, Li Wei

Journal Article

Size-dependent Elastic Instability of Gel CylinderWith Surface Stress

Huang Dianwu,Qiao Ling, Wang Shiji

Journal Article

Modulational Instability of Optical Vortices in Engineered Saturable Media

D.G. Pires, N.M. Litchinitser

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Underlying mechanism of the hydrothermal instability of Cu

Nadeen Al-Janabi,Abdullatif Alfutimie,Flor R. Siperstein,Xiaolei Fan

Journal Article

MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Journal Article

Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Journal Article

p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by

Hui Han,Yanjia Chen,Zhengbin Zhu,Xiuxiu Su,Jingwei Ni,Run Du,Ruiyan Zhang,Wei Jin

Journal Article

Aerodynamic stability evolution tendency of suspension bridges with spans from 1000 to 5000 m

Journal Article

Stability of an annular viscous liquid jet in compressible gases with different properties inside and outside of the jet

Chunji YAN, Maozhao XIE,

Journal Article

Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training for anesthesiologists?

Yong G. Peng, Gregory M. Janelle

Journal Article